Distribution of the 4F2 light chain, LATI, in the mouse brain

Citation
T. Kageyama et al., Distribution of the 4F2 light chain, LATI, in the mouse brain, NEUROREPORT, 11(17), 2000, pp. 3663-3666
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
11
Issue
17
Year of publication
2000
Pages
3663 - 3666
Database
ISI
SICI code
0959-4965(20001127)11:17<3663:DOT4LC>2.0.ZU;2-J
Abstract
LAT1 (the 4F2-light chain I) is a component of the CD98 surface antigen whi ch participates in multiple functions including amino acid transport, cell survival, cell fusion and integrin activation. We examined the distribution of LAT1 in the mouse brain using immunohistochemistry. LAT1 was expressed on the microvessels, the subfornical organ, the subcommissural organ, ventr omedial nucleus of the hypothalamus, subgranular zone of the dentate gyrus, ependymal layer of the lateral ventricles, and the olfactory bulb. LAT1-po sitive cells incorporated bromodeoxyuridine in the latter three regions whe re neurogenesis occurs in adult mouse brain, indicating that LAT1 is involv ed in neuronal cell proliferation, as well as in amino acid transport in th ese regions. NeuroReport 11:3663-3666 (C) 2000 Lippincott Williams & Wilkin s.