1,2-Dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenzo [a,l]pyrene-DNA adduction in female Sprague-Dawley rats

Citation
Wa. Smith et al., 1,2-Dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenzo [a,l]pyrene-DNA adduction in female Sprague-Dawley rats, INT J CANC, 91(1), 2001, pp. 132-136
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF CANCER
ISSN journal
0020-7136 → ACNP
Volume
91
Issue
1
Year of publication
2001
Pages
132 - 136
Database
ISI
SICI code
0020-7136(20010101)91:1<132:1AISAO>2.0.ZU;2-I
Abstract
Dithiolethiones are currently one of the most promising classes of cancer c hemopreventive agents that exhibit antitumorigenic properties at numerous o rgan sites against several classes of carcinogens. In the current study, we examined the effects of 2 dithiolethiones, 1,2-dithiole-3-thione (D3T) and its structural analogue oltipraz, on DNA adduction induced by the potent m ammary carcinogen dibenzo[a,/]pyrene (DBP) in vivo. Female Sprague-Dawley r ats were provided dietary D3T and oltipraz (500 ppm each) for I week follow ed by a single intragastric dose of DBP (8 mu mol/kg body weight) and kille d 5 days later. D3T inhibited DBP-DNA adduction from 78% to 82% in all tiss ues examined, while oltipraz was equally effective in the lung and liver bu t less effective in the mammary glands, inhibiting DBP-DNA adduction by nea rly 60%, These data coupled with their broad anti-tumor specificity support the use of D3T and oltipraz as cancer-preventive agents in clinical trials , (C) 2001 Wiley-Liss, Inc.