Variability in CD34+cell counts in umbilical cord blood: Implications for cord blood transplants

Citation
C. Yap et al., Variability in CD34+cell counts in umbilical cord blood: Implications for cord blood transplants, GYNECOL OBS, 50(4), 2000, pp. 258-259
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
50
Issue
4
Year of publication
2000
Pages
258 - 259
Database
ISI
SICI code
0378-7346(2000)50:4<258:VICCIU>2.0.ZU;2-T
Abstract
Objective: To determine if total nucleated cell counts alone are sufficient for predicting the efficacy of cord blood units for transplant from neonat al umbilical cord blood samples. Methods: Umbilical cord blood samples were collected from 200 mothers at de livery and the cord blood units processed, The total nucleated cells and CD 34+ cells were enumerated and compared for each sample. Results: Despite an apparent linear correlation between total nucleated cel l counts and CD34+ cell counts, each group of total nucleated cell counts d emonstrated a high degree of variation in CD34+ cell counts and could be as low as 0.1% of total nucleated cell counts. Conclusions: Large variations in CD34+ cell counts per total nucleated cell count are present for cord blood units from neonatal umbilical cord sample s. Hence a CD34+ cell count for each cord blood unit would improve selectio n of samples for transplant. Copyright (C) 2000 S. Karger AG, Basel.