Effect of acupuncture treatment on uterine motility and cyclooxygenase-2 expression in pregnant rats

Citation
Js. Kim et al., Effect of acupuncture treatment on uterine motility and cyclooxygenase-2 expression in pregnant rats, GYNECOL OBS, 50(4), 2000, pp. 225-230
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
50
Issue
4
Year of publication
2000
Pages
225 - 230
Database
ISI
SICI code
0378-7346(2000)50:4<225:EOATOU>2.0.ZU;2-M
Abstract
As the pregnancy stage advances, prostaglandin (PG) concentrations increase in the uterus, being responsible for the increased uterus contractility du ring labor. Therefore, regulating the concentration of the PGs in the uteru s is important for controlling preterm delivery. In oriental medicine tradi tionally, an acupuncture of LI-4 controls for the function and motility of the uterus. In this study, acupuncture treatment on the LI-4 acupoint in no npregnant and pregnant rats was evaluated for its efficacy in the expressio n of COX-2 enzyme and uterus motility. Whether the rats were pregnant or no t, immunohistochemical localization of the COX-2 enzyme was primarily found in the uterine endometrium with weak localization in the uterine myometriu m. The level of expression in these two locations was intensified by pregna ncy but reduced by the LI-4 acupuncture. The infusion of PGF2(alpha) in pre gnant rats caused and increased COX-2 expression in the myometrium while it caused a decreased expression in the endometrium. The uterus motility moni tored during the LI-4 acupuncture reduced to 67.0% in nonpregnant rats, and to 75.0% in pregnant rats. PGF2(alpha) infusion in pregnant rats increased uterine motility to 117.3%. The significant reduction in uterus motility i n pregnant rats supports the role of LI-4 acupuncture in inhibiting the exp ression of COX-2 enzyme that can be used to regulate complicated preterm la bor.Copyright (C) 2000 S. Karger AG, Basel.