Risk factors for genital prolapse in non-hysterectomized women around menopause - Results from a large cross-sectional study in menopausal clinics inItaly

Authors
De Aloysio, D Di Donato, P Giulini, NA Modena, B Cicchetti, G Comitini, G Gentile, G Cristiani, P Careccia, A Esposito, E Gigli, C Mandruzzato, G Petraglia, F Bertelli, F Del Frate, G Garofalo, S Marino, L Costa, MR Quaranta, S Bossi, CM Amantea, P Omodei, U Vaccari, M Luerti, M Repetti, F Zandonini, G Raspagliesi, F Dolci, F Zacchi, V Bennici, S Polizzotti, G Bottino, S Raffaelli, F Minervini, C Colombo, D Belloni, C Viani, A Cecchini, G Winkler, S Samaja, BA Pasinetti, E Penotti, M Malanetto, C Massobrio, M Campagnoli, C Dolfin, G Tartaglino, P Mossotto, D Pesando, P Pacilli, L Rattazzi, PD Arisi, E Gamper, M Salvatores, D Bocchin, E Stellin, G Meli, G Azzini, V Tirozzi, F Buoso, G Fraioli, R Marsoni, V Cetera, C Sposetti, R Bellati, U Angeloni, C Buonerba, M Garzarelli, S Santilli, C Mucci, M Di Nisio, Q Falasca, L Ferrante, D Cirese, E Todaro, PA Romanini, C Spagnuolo, L Lanzone, A Donadio, C Fabiani, M Baldaccini, E Votano, S Serra, GB Bellardini, P Massacesi, L Donini, G Genazzani, RA Scarselli, G Curiel, P De Leo, V Melani, A D'Ancona, VL Giarre, G Di Gioia, E Ciccarelli, P Sarti, CD Balsotti, G Pupita, P Mincigrucci, M Spadafora, A Santeufemia, G D'Andrea, A Chiantera, A Montemagno, U Staiano, S Arienzo, R Pastore, AR Tamburrino, A Colacurci, A Izzo, S Zumpano, N Pascarella, A De Silvio, MG Di Prisco, L Lauda, N Sorrentino, O Agrimi, C Casarella, G Pisaturo, G Senatore, G Ruccia, G Fasolino, A Tropea, P Stigliano, CM Giannice, C Vadala, P Coco, A Lombardo, R Barese, G Masciari, G Pirillo, P Gioffre, T Ferruccio, C Agostinelli, D Tonti, GC Scopelliti, A Schonauer, S Bongiovanni, F Tinelli, F Poddi, ER Scarpello, F Colonna, L Fischetti, G Doria, R Trombetta, G Cocca, EB Carone, D Nocera, F Giambanco, V Giannola, C Graziano, R Mezatesta, M Vegna, G Giannone, G Palumbo, G Cancellieri, F Mondo, A Cordopatri, A Carrubba, M Mazzola, V Ettore, G D'Asta, S Di Liberto, P Massacesi, A Chiantera, A Sarti, CD De Aloysio, P Omodei, U Ognissanti, F Campagnoli, C Penotti, M Gambacciani, A Graziottin, A Baldi, C Parazzini, F Chatenoud, L Chiaffarino, F
Citation
D. De Aloysio et al., Risk factors for genital prolapse in non-hysterectomized women around menopause - Results from a large cross-sectional study in menopausal clinics inItaly, EUR J OB GY, 93(2), 2000, pp. 135-140
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
ISSN journal
0301-2115 → ACNP
Volume
93
Issue
2
Year of publication
2000
Pages
135 - 140
Database
ISI
SICI code
0301-2115(200012)93:2<135:RFFGPI>2.0.ZU;2-R
Abstract
Objective: To analyze determinants/risk factors for uterine prolapse in a p opulation of women around menopause. Methods: Between 1997 and 1999, we con ducted a large cross sectional study on the characteristics of women around menopause attending a network of first level outpatients menopause clinics in Italy for general counselling about menopause or treatment of menopausa l symptoms. Eligible for the study were women consecutively observed during the study period. All women underwent a gynecological examination. Results : Considering the 21 449 non-hysterectomized women, uterine prolapse was di agnosed in 1182 cases (5.5%). Of those, 772 (65.3%) had prolapse degree I a nd 410 (34.7%) degree II or III. The frequency of uterine prolapse increase s with age: In comparison with women aged less than or equal to 51 years, t he odds ratio OR of uterine prolapse was 1.3 and 1.7 respectively for women aged 52-55 and greater than or equal to 56 years. In comparison with women with none/primary education, the OR of uterine prolapse was 0.8 (95% confi dential interval CI 0.7-0.9) and 0.8 (95% CI 0.6-0.9), respectively, for wo men with intermediate or high school/university degree. The risk of uterine prolapse increased with body mass index (BMI; kg/m(2)) value: In compariso n with women with BMI<23.8, the OR was 1.4 (95% CI 1.2-1.7) and 1.6 (95% CI 1.3-1.9) for women with BMI 23.8-27.2 and >27.2. In comparison with nullip arae, the OR of uterine prolapse increased with number of births, being 3.0 (95% CI 2.1-4.3) in women reporting greater than or equal to3 births. A hi story of caesarean section or of a delivery of a fetus weighing >4500 g wer e not associated with increased risk of uterine prolapse. When the analysis was conducted separately in strata of grade of uterine prolapse (I and gre ater than or equal to II), no marked differences emerged in the OR estimate s. Conclusions: This study indicates that, in this population, the risk of uterovaginal prolapse increase with the number of vaginal births and was hi gher in overweight women, offering some quantitative estimates of the role of these factors on the risk of the condition. (C) 2000 Elsevier Science Ir eland Ltd. All rights reserved.