The prevalence of anergy in human immunodeficiency virus-infected adolescents and the association of delayed-type hypersensitivity with subject characteristics

Citation
As. Rogers et al., The prevalence of anergy in human immunodeficiency virus-infected adolescents and the association of delayed-type hypersensitivity with subject characteristics, J ADOLES H, 27(6), 2000, pp. 384-390
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public Health & Health Care Science",Pediatrics
Journal title
JOURNAL OF ADOLESCENT HEALTH
ISSN journal
1054-139X → ACNP
Volume
27
Issue
6
Year of publication
2000
Pages
384 - 390
Database
ISI
SICI code
1054-139X(200012)27:6<384:TPOAIH>2.0.ZU;2-S
Abstract
Purpose: To examine the prevalence of anergy in HIV-infected adolescents an d factors associated with its occurrence. Methods: Anergy was defined as less than 2mm induration to each of three in tradermally applied antigens (Candida albicans, tetanus toroid, and mumps) between 24 and 96 hours in a population of HIV-infected adolescents aged 12 -18 at entry in a national multicenter study of HIV disease progression. CD 4(+) T-cell counts and plasma HIV-1 RNA were measured in quality controlled laboratories. Factors associated with the probability of anergy were exami ned with contingency table comparisons, tree-structured classification, and logistic regression analyses. Results: Overall prevalence of anergy in this clinic-based population of 16 7 was 11% [7% in males and 12% in females (p = 0.57)]. The sole significant predictor of anergy was decreased CD4(+) T-cell count (p = 0.005). Conclusion: The prevalence of anergy is low in this HIV-infected population compared to older infected cohorts. The occurrence of differential rates o f anergy in particular age and sex groupings that may be related to intrins ic immunologic differences requires further study. (C) Society for Adolesce nt Medicine, 2000.