As. Rogers et al., The prevalence of anergy in human immunodeficiency virus-infected adolescents and the association of delayed-type hypersensitivity with subject characteristics, J ADOLES H, 27(6), 2000, pp. 384-390
Purpose: To examine the prevalence of anergy in HIV-infected adolescents an
d factors associated with its occurrence.
Methods: Anergy was defined as less than 2mm induration to each of three in
tradermally applied antigens (Candida albicans, tetanus toroid, and mumps)
between 24 and 96 hours in a population of HIV-infected adolescents aged 12
-18 at entry in a national multicenter study of HIV disease progression. CD
4(+) T-cell counts and plasma HIV-1 RNA were measured in quality controlled
laboratories. Factors associated with the probability of anergy were exami
ned with contingency table comparisons, tree-structured classification, and
logistic regression analyses.
Results: Overall prevalence of anergy in this clinic-based population of 16
7 was 11% [7% in males and 12% in females (p = 0.57)]. The sole significant
predictor of anergy was decreased CD4(+) T-cell count (p = 0.005).
Conclusion: The prevalence of anergy is low in this HIV-infected population
compared to older infected cohorts. The occurrence of differential rates o
f anergy in particular age and sex groupings that may be related to intrins
ic immunologic differences requires further study. (C) Society for Adolesce
nt Medicine, 2000.