The use of dexamethasone for preventing postoperative nausea and vomiting in females undergoing thyroidectomy: A dose-ranging study

Citation
Jj. Wang et al., The use of dexamethasone for preventing postoperative nausea and vomiting in females undergoing thyroidectomy: A dose-ranging study, ANESTH ANAL, 91(6), 2000, pp. 1404-1407
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
ANESTHESIA AND ANALGESIA
ISSN journal
0003-2999 → ACNP
Volume
91
Issue
6
Year of publication
2000
Pages
1404 - 1407
Database
ISI
SICI code
0003-2999(200012)91:6<1404:TUODFP>2.0.ZU;2-4
Abstract
We sought to determine the minimum effective dose of dexamethasone in preve nting postoperative nausea and vomiting in women undergoing thyroidectomy. Two hundred twenty-five women (n = 45 in each of five groups) undergoing th yroidectomy under general anesthesia were enrolled in this randomized, doub le-blinded, placebo-controlled study. Immediately after the induction of an esthesia, patients received IV dexamethasone at doses of 10 mg (D10), 5 mg (D5), 2.5 mg (D2.5), 1.25 mg (D1.25), or saline (S). We found that Groups D 10 and D5 were significantly different from Group S in the total incidences of nausea and vomiting, more than four vomiting episodes, the proportions of patients requiring rescue antiemetics, and the incidences of complete re sponses. The differences between Groups D10 and D5 were not significant. De xamethasone 2.5 mg reduced the total incidence of nausea and vomiting. Dexa methasone 1.25 mg was not effective. Dexamethasone 5 mg IV is the minimum e ffective dose in preventing postoperative nausea and vomiting in women unde rgoing thyroidectomy.