Adverse influence of numbers of previous miscarriages on results of paternal lymphocyte immunization in patients with recurrent spontaneous abortions

Citation
K. Katano et al., Adverse influence of numbers of previous miscarriages on results of paternal lymphocyte immunization in patients with recurrent spontaneous abortions, AM J REPROD, 44(5), 2000, pp. 289-292
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
44
Issue
5
Year of publication
2000
Pages
289 - 292
Database
ISI
SICI code
1046-7408(200011)44:5<289:AIONOP>2.0.ZU;2-T
Abstract
PROBLEM: To determine whether an increase in the number of previous miscarr iages in recurrent spontaneous abortion patients is a risk factor in subseq uent pregnancies with paternal lymphocyte immunotherapy. METHOD OF STUDY: Live birth rates with reference to previous abortion numbe rs in recurrent spontaneous abortion patients were statistically compared b etween paternal lymphocyte immunotherapy and control groups, the latter ret rospectively researched using historical data before 1981 in our clinic. RESULTS: The overall live birth rate was 73% (169/232) in the immunotherapy group, and 48% (47/97) in controls (P < 0.05). According to previous abort ion numbers, the rates were 77% (114/148) versus 55% (36/65) (P < 0.05) for three previous abortions, 70% (40157) versus 38% (8/21) (P < 0.05) for fou r and 56% (15/27) Versus 27% (3/11) (not significant) for five, in the stud y and control groups, respectively. CONCLUSIONS: The results confirm the efficacy of paternal lymphocyte immuno therapy, but demonstrate that the success rate deteriorates with the number of previous miscarriages.