K. Katano et al., Adverse influence of numbers of previous miscarriages on results of paternal lymphocyte immunization in patients with recurrent spontaneous abortions, AM J REPROD, 44(5), 2000, pp. 289-292
PROBLEM: To determine whether an increase in the number of previous miscarr
iages in recurrent spontaneous abortion patients is a risk factor in subseq
uent pregnancies with paternal lymphocyte immunotherapy.
METHOD OF STUDY: Live birth rates with reference to previous abortion numbe
rs in recurrent spontaneous abortion patients were statistically compared b
etween paternal lymphocyte immunotherapy and control groups, the latter ret
rospectively researched using historical data before 1981 in our clinic.
RESULTS: The overall live birth rate was 73% (169/232) in the immunotherapy
group, and 48% (47/97) in controls (P < 0.05). According to previous abort
ion numbers, the rates were 77% (114/148) versus 55% (36/65) (P < 0.05) for
three previous abortions, 70% (40157) versus 38% (8/21) (P < 0.05) for fou
r and 56% (15/27) Versus 27% (3/11) (not significant) for five, in the stud
y and control groups, respectively.
CONCLUSIONS: The results confirm the efficacy of paternal lymphocyte immuno
therapy, but demonstrate that the success rate deteriorates with the number
of previous miscarriages.