Chromosome studies in patients with defective reproductive success

Citation
Ar. Badovinac et al., Chromosome studies in patients with defective reproductive success, AM J REPROD, 44(5), 2000, pp. 279-283
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
44
Issue
5
Year of publication
2000
Pages
279 - 283
Database
ISI
SICI code
1046-7408(200011)44:5<279:CSIPWD>2.0.ZU;2-S
Abstract
PROBLEM: The objective of this study was to evaluate the contribution of ch romosomal anomalies to decreased fertility in humans. METHOD OF STUDY: In order to investigate the aetiology of infertility in ou r population and to assess the karyotype in a group of infertile couples an d individuals with fertility problems, 782 persons (259 couples, 158 male a nd 106 Female) with different clinical diagnoses of sterility and infertili ty were analysed cytogenetically. RESULTS: The overall frequency of major chromosomal aberration was 13.1% (1 03/783), which suggests that fertility or sterility problems in this popula tion are due to chromosomal aberrations. Couples experiencing repeated spon taneous abortions, having malformed children or having sterility problems h ad chromosomal abnormalities in 18.0% (47/259 couples) of the population st udied, and constituted chromosomal disorders occured in couples seeking IVF and ICSI with prevalence of 22.2% (8/38 couples), especially minor mosaici sm of sex chromosomes in the female partners. The prevalence of chromosome abnormalities in infertile men was 17.7% (28/158), and in subfertile female s, it was 26.4% (28/106). CONCLUSIONS: These results could indicate an increased tendency to miotic s ex chromosome non-disjuction in humans.