Immunocontraception of white-tailed deer with GnRH vaccine

Citation
La. Miller et al., Immunocontraception of white-tailed deer with GnRH vaccine, AM J REPROD, 44(5), 2000, pp. 266-274
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
44
Issue
5
Year of publication
2000
Pages
266 - 274
Database
ISI
SICI code
1046-7408(200011)44:5<266:IOWDWG>2.0.ZU;2-G
Abstract
PROBLEM: Reduction of excess numbers of white-tailed deer (Odocoileus virgi nianus) is an example of a potential use for immunocontraception as a means of wildlife population management. METHOD OF STUDY: A 4 year multifaceted study was conducted to determine the long term effects of gonadotropin releasing hormone (GnRH) contraceptive v accine on the fertility and behavior of female and male white-tailed deer. Deer were monitored for breeding behavior, hormone levels, pregnancy, fawni ng and GnRH specific antibody levels. RESULTS: Treatment lead to reduced fawning rates, altered estrus behavior, reduced concentrations of progesterone, contraception and failure to mainta in pregnancy following conception. GnRH immunized does bred to untreated bu cks had an 88% reduction in fawning caused by either immunocontraception or immunocontragestion. The vaccine effect is reversible, directly related to the antibody titer. Infertility lasted up to two years without boosting. G nRH immunized bucks demonstrated no interest in sexual activity when paired with control females. Depending on the immunization schedule, antlers eith er dropped early or remained in velvet. CONCLUSIONS: The results of this study demonstrate that GnRH vaccine is eff ective in inducing a reversible infertility in white-tailed deer, the infer tility lasting up to two years without boosting.