Pregnancy outcome and ovarian antibodies in infertility patients undergoing controlled ovarian hyperstimulation

Citation
J. Luborsky et R. Pong, Pregnancy outcome and ovarian antibodies in infertility patients undergoing controlled ovarian hyperstimulation, AM J REPROD, 44(5), 2000, pp. 261-265
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
44
Issue
5
Year of publication
2000
Pages
261 - 265
Database
ISI
SICI code
1046-7408(200011)44:5<261:POAOAI>2.0.ZU;2-J
Abstract
PROBLEM: Several endocrine markers are well-established, but not absolute, predictors of successful outcomes following controlled ovarian hyperstimula tion. Another potential predictor for success may be a marker of ovarian au toimmunity. Ovarian antibodies (OVAB) are detected in women with unexplaine d infertility. We tested the hypothesis that women with OVAB have a poorer pregnancy outcome in in vitro fertilization (IVF). METHOD OF STUDY: Serum samples (n=47) were assessed by a previously describ ed immunoassay for OVAB in a cross-sectional, retrospective study design. RESULTS: Women who became pregnant had a lower frequency of OVAB than women who did not become pregnant (25.0% [4/16] vs. 58.1% [18/31], respectively; P = 0.03). There was no significant difference in day 3 estradiol, amount of human menopausal gonadotropin given, peak estradiol, the number of folli cles observed, or the number of eggs retrieved between women who achieved p regnancy and those who did not. CONCLUSIONS: Together with other information such as reproductive hormone l evels and measures of follicle growth, OVAB may contribute additional infor mation for prediction of successful IVF outcomes.