PROBLEM: Several endocrine markers are well-established, but not absolute,
predictors of successful outcomes following controlled ovarian hyperstimula
tion. Another potential predictor for success may be a marker of ovarian au
toimmunity. Ovarian antibodies (OVAB) are detected in women with unexplaine
d infertility. We tested the hypothesis that women with OVAB have a poorer
pregnancy outcome in in vitro fertilization (IVF).
METHOD OF STUDY: Serum samples (n=47) were assessed by a previously describ
ed immunoassay for OVAB in a cross-sectional, retrospective study design.
RESULTS: Women who became pregnant had a lower frequency of OVAB than women
who did not become pregnant (25.0% [4/16] vs. 58.1% [18/31], respectively;
P = 0.03). There was no significant difference in day 3 estradiol, amount
of human menopausal gonadotropin given, peak estradiol, the number of folli
cles observed, or the number of eggs retrieved between women who achieved p
regnancy and those who did not.
CONCLUSIONS: Together with other information such as reproductive hormone l
evels and measures of follicle growth, OVAB may contribute additional infor
mation for prediction of successful IVF outcomes.