Electron and photon spectra for three gadolinium-based cancer therapy approaches

Citation
T. Goorley et H. Nikjoo, Electron and photon spectra for three gadolinium-based cancer therapy approaches, RADIAT RES, 154(5), 2000, pp. 556-563
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
RADIATION RESEARCH
ISSN journal
0033-7587 → ACNP
Volume
154
Issue
5
Year of publication
2000
Pages
556 - 563
Database
ISI
SICI code
0033-7587(200011)154:5<556:EAPSFT>2.0.ZU;2-L
Abstract
Some recent neutron capture therapy research has focused on using compounds containing the element gadolinium, which produces internal conversion and Auger cascade electrons, The low-energy, short-range Auger electrons are ab sorbed locally and increase cell killing dramatically as the gadolinium com pounds are introduced into the cell nucleus and bind to the DNA, Detailed e lectron and photon spectra are needed for biophysical modeling and Monte Ca rlo calculations of damage to DNA, This paper presents calculated electron and photon spectra for three cases: thermal neutron absorption by Gd-157, t he beta -particle decay of Gd-159,and the K-shell photoelectric event in ga dolinium. The Monte Carlo sampling of atomic and nuclear transitions for ea ch of the three cases was used to calculate a large number of representativ e decays, The sampled decays were used to determine average emissions and e nergy deposited in small spheres of tissue. The kinetic energy nuclear reco il from gamma -ray and electron emissions was calculated and found to be mo re than 10 eV for 26% of all Gd-157 neutron capture reactions. (C) 2000 by Radiation Research Society.