Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung

Citation
Y. Hosomi et al., Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung, LUNG CANC, 30(2), 2000, pp. 73-81
Citations number
42
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
LUNG CANCER
ISSN journal
0169-5002 → ACNP
Volume
30
Issue
2
Year of publication
2000
Pages
73 - 81
Database
ISI
SICI code
0169-5002(200011)30:2<73:IC2(EO>2.0.ZU;2-R
Abstract
A low incidence of lung carcinoma has been reported in cases of prolonged u se of aspirin. Cyclooxygenase (COX) expression is frequently seen in adenoc arcinoma of the lung, but COX-2 expression in atypical adenomatous hyperpla sia (AAH), a possible precursor lesion of adenocarcinoma of the lung, is no t known. COX-2 expression was immunohistochemically evaluated in a cohort o f 20 cuboidal cell hyperplasias (CCH), 81 atypical adenomatous hyperplasias (AAH), 18 bronchioloalveolar carcinomas (BAC), and 88 invasive adenocarcin omas (I-Ad). The relationship between COX-2 expression and clinicopathologi c factors and survival was examined. COX-2 overexpression was detected in o ver 80% of CCH, AAH, BAC, and I-Ad. However. overexpression was diffuse in AAH (71.6%) and BAC (66.7%). No relationship was found between COX-2 expres sion and clinicopathological factors or survival. COX-2 expression was most frequently detected in AAH. These findings, taken with previous reports th at treatment with COX-2 inhibitor suppresses human colon carcinogenesis, su ggest that inhibition of COX-2 may reduce the incidence of human adenocarci noma of the lung. (C) 2000 Elsevier Science Ireland Ltd. All rights reserve d.