Prevalence of hepatitis G virus (HGV) infection in an endemic area of hepatitis C virus (HCV) infection

Citation
M. Kitano et al., Prevalence of hepatitis G virus (HGV) infection in an endemic area of hepatitis C virus (HCV) infection, HEP-GASTRO, 47(35), 2000, pp. 1340-1342
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
HEPATO-GASTROENTEROLOGY
ISSN journal
0172-6390 → ACNP
Volume
47
Issue
35
Year of publication
2000
Pages
1340 - 1342
Database
ISI
SICI code
0172-6390(200009/10)47:35<1340:POHGV(>2.0.ZU;2-G
Abstract
Background/Aims: We investigated the prevalence of hepatitis G virus infect ion among inhabitants of a hepatitis C virus endemic area. Methodology: Two hundred and eighty-eight inhabitants, who underwent medica l examinations for health screening, were enrolled in this epidemiological study. HGV RNA and HCV RNA were detected by polymerase chain reaction. We a lso examined anti-HGV envelope protein (E2) antibodies in all serum samples . Results: In these 288 inhabitants, we found anti-HCV antibodied (HCV-Ab) an d HCV RNA in 28.5% and 17.4%, respectively. HGV RNA and anti-HGV E2 were de tected in 9 (3.1%) and 16 (5.5%), respectively. One patient was positive fo r both HGV RNA and anti-HGV E2. The exposure rate, expressed as the percent age of people with HGV RNA and/or anti-HGV E2, war: 8.3%, which was signifi cantly lower than the incidence of positive HCV-Ab. Of the 24 patients with HGV RNA and/or anti-HGV E2, 15 (62.5%) were positive for HCV-Ab, of those HCV RNA was detected in 9 (37.5%). Further, we found a higher prevalence of HGV exposure in patients with HCV-Ab than in those without (8.3% vs. 4.4%) . Conclusions: HGV infection was not identical to the epidemic hepatitis C vi rus infection among:inhabitants of this town, suggesting that hepatitis, G virus might be less infectious than hepatitis C virus.