Pulmonary venous flow velocity: relationship with left atrial compliance and left atrial pressure

Citation
T. Hofmann et al., Pulmonary venous flow velocity: relationship with left atrial compliance and left atrial pressure, EUR H J SUP, 2(K), 2000, pp. K69-K75
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
EUROPEAN HEART JOURNAL SUPPLEMENTS
ISSN journal
1520-765X → ACNP
Volume
2
Issue
K
Year of publication
2000
Pages
K69 - K75
Database
ISI
SICI code
1520-765X(200011)2:K<K69:PVFVRW>2.0.ZU;2-E
Abstract
Aims The aim of the study was to evaluate the relationship between pulmonar y venous flow velocity and left atrial pressure and to derive a multivariat e regression model for the estimation of mean left atrial pressure. Methods and Results A total of 40 patients undergoing elective coronary art ery bypass grafting were included in the study. All measurements were perfo rmed 6-8 h after the operation in haemodynamically stable patients. We foun d a decrease of the ratio of peak systolic to diastolic pulmonary venous fl ow velocity (S/D ratio) with increasing mean left atrial pressure (r=- 0/87 0, P<0.0001). An increase of mean left atrial pressure reduced systolic pul monary venous peak velocity (r=- 0.409, P<0.01) while diastolic peak veloci ty was unchanged (r=0.134, P=ns). Furthermore, we found an inverse correlat ion between left atrial compliance and mean left atrial pressure(r=-0.757, P<0.001). Using stepwise linear multivariate regression analysis the S/D ra tio, the time from the Q wave to maximum antegrade pulmonary venous flow ve locity (t-v(max)) and left atrial shortening fraction were identified as in dependent predictors of mean left atrial pressure. Conclusions Mean left atrial pressure is an important determinant of the pa ttern of the pulmonary venous flow waveform. The decrease of pulmonary veno us S/D ratio with rising mean left atrial pressure could be mainly explaine d by a decrease of left atrial compliance with increasing mean left atrial pressure.