Caenorhabditis elegans contains a third Polo-like kinase gene

Citation
D. Chase et al., Caenorhabditis elegans contains a third Polo-like kinase gene, DNA SEQ, 11(3-4), 2000, pp. 327-334
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
DNA SEQUENCE
ISSN journal
1042-5179 → ACNP
Volume
11
Issue
3-4
Year of publication
2000
Pages
327 - 334
Database
ISI
SICI code
1042-5179(2000)11:3-4<327:CECATP>2.0.ZU;2-4
Abstract
The Polo family of serine/ threonine kinases have been implicated in cell c ycle control in a number of diverse organisms. Their localization and bioch emical activity suggest that they play an important role in centrosome matu ration, G2-to-M phase progression, the promotion of anaphase, and cytokines is. The Polo family of kinases is distinct from other serine/threonine kina ses in that they all contain a polo-box sequence motif in their non-catalyt ic C-terminal domain. Recently, it was reported that two Polo-related kinas es, Plc1 and Plc2, are present in C. elegans. Plc2 has diverged from Plc1 w ith poor homology within the polo-box sequence and only had 40% amino acid identity with Plc1. We report here the full-length cDNA sequence of another Polo-related kinase from C. elegans. The predicted protein product has gre ater than 70% amino acid identity with PLK-1/Plc1, and has a highly conserv ed polo-box domain.