Proteins shared by the transcription and translation machines

Citation
Cl. Squires et D. Zaporojets, Proteins shared by the transcription and translation machines, ANN R MICRO, 54, 2000, pp. 775-798
Citations number
91
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
54
Year of publication
2000
Pages
775 - 798
Database
ISI
SICI code
0066-4227(2000)54:<775:PSBTTA>2.0.ZU;2-J
Abstract
It is becoming increasingly clear that the complex machines involved in tra nscription and translation, the two major activities leading to gene expres sion, communicate directly with one another by sharing proteins. For some p roteins, such as ribosomal proteins S10 and L4, there is strong evidence of their participation in both processes, and much is known about their role in both activities. The exact roles and interactions of other proteins, suc h as Nus factors B and G, in both transcription and translation remain a my stery. Although there are not, at present, many examples of such shared pro teins, the importance of understanding their behavior and intimate involvem ent with two major cellular machines is beginning to be appreciated. Studie s related to the dual activities of these proteins and searches for more ex amples of proteins shared between the transcription and translation machine s should lead to a better understanding of the communication between these two activities and the purposes it serves.