Moraxella catarrhalis pneumonia during HIV disease

Citation
R. Manfredi et al., Moraxella catarrhalis pneumonia during HIV disease, J CHEMOTHER, 12(5), 2000, pp. 406-411
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology
Journal title
JOURNAL OF CHEMOTHERAPY
ISSN journal
1120-009X → ACNP
Volume
12
Issue
5
Year of publication
2000
Pages
406 - 411
Database
ISI
SICI code
1120-009X(200010)12:5<406:MCPDHD>2.0.ZU;2-K
Abstract
To assess the role of Moraxella catarrhalis complications in the setting of HIV disease, and to evaluate their occurence and outcome according to seve ral epidemiological, clinical, and laboratory parameters, the clinical reco rds of 2123 consecutive HIV-infected patients hospitalized in a 9-year peri od were retrospectively reviewed, and 4 cases of community-acquired M, cata rrhalis pneumonia were identified. Three adult patients had a diagnosis of AIDS and severe concurrent immunodeficiency (with a CD4+ lymphocyte count b elow 60 cells/muL), while the fourth case involved a child with vertical HI V disease. Leukopenia and neutropenia were never present, but no patient re ceived a potent antiretroviral regimen at the time of disease onset, A conc urrent respiratory infection by Streptococcus pneumoniae and Mycobacterium tuberculosis was recognized in 2 of 4 patients. Isolated M. catarrhalis str ains were susceptible to all tested antimicrobial compounds (save ampicilli n in 2 cases), and appropriate antimicrobial treatment led to clinical and microbiological cure in all described episodes. Only 8 cases of HIV-associa ted Moraxella spp. disease have been reported to date in seven different li terature reports (6 cases of pneumonia, and 1 of septicemia). According to our experience, M. catarrhalis may be responsible for appreciable morbidity among patients with advanced HIV infection, especially when a low CD4+ cel l count or coexisting respiratory disease are present, Clinicians and micro biologists who care for HIV-infected patients should carefully consider the potential pathogenic role of Moraxella spp, organisms.