Sterol evolution and the physics of membranes

Citation
M. Nielsen et al., Sterol evolution and the physics of membranes, EUROPH LETT, 52(3), 2000, pp. 368-374
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physics
Journal title
EUROPHYSICS LETTERS
ISSN journal
0295-5075 → ACNP
Volume
52
Issue
3
Year of publication
2000
Pages
368 - 374
Database
ISI
SICI code
0295-5075(200011)52:3<368:SEATPO>2.0.ZU;2-8
Abstract
Sterols are important molecular components of the plasma membranes of eucar yotic cells. Using deuterium NMR spectroscopy in conjunction with statistic al mechanical modelling, we present a unifying picture of how the evolution -engineered differences in molecular chemistry between cholesterol and its precursor lanosterol are manifested in the physical properties of model mem branes in terms of molecular order and phase equilibria. Cholesterol optimi zes the stability of a particular membrane phase, the liquid-ordered phase, that is a liquid and at the same time exhibits high molecular conformation al order.