Forced ethanol treatment stimulates and inhibits ethanol intake in a rat model of alcoholism

Citation
L. Hedlund et G. Wahlstrom, Forced ethanol treatment stimulates and inhibits ethanol intake in a rat model of alcoholism, ALC ALCOHOL, 35(5), 2000, pp. 446-451
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
ALCOHOL AND ALCOHOLISM
ISSN journal
0735-0414 → ACNP
Volume
35
Issue
5
Year of publication
2000
Pages
446 - 451
Database
ISI
SICI code
0735-0414(200009/10)35:5<446:FETSAI>2.0.ZU;2-R
Abstract
In a model of psychological dependance, a very stable ethanol intake was in duced by a chronic (1-year) intermittant (once a week exposure to intoxicat ing amounts of ethanol (24 h choice between ethanol and water, follow ed by 2.0 g/kg i.p.) After this year, the rats had continuous access to ethanol and water. Stability was shown by the ability of the rats to take the same dose of ethanol tin g/kg) when the concentration was changed from 10 to 20% . To study possible priming or inhibiting effects on ethanol intake. ethano l was injected i.p.. first as 20%, 40% or 60% of the intake in the 24 h pri or to the injection, then as fixed doses of 0.5, 1, and 2 g/kg, and the eth anol intake during the following 24-h period was recorded. The results show ed that, following a low dose of ethanol, voluntary ethanol intake was incr eased in rats with a low and decreased in rats with a high, ethanol intake, while high doses of ethanol seemed to decrease voluntary ethanol intake in all rats. The results are discussed in relation to theories about loss of control of drinking and relapse in humans.