The effect of methylene blur on the disposition of ethanol was studied in r
ats and humans. Methylene blue increased the metabolism of [C-14]ethanol to
(CO2)-C-14 in isolated hepatocytes and in intact rats by 75% and 30%, resp
ectively. In healthy volunteers, methylene blue did not affect the pharmaco
kinetics of ethanol and did nor alleviate the ethanol-induced NAD redox; ch
anges as reflected by the increase in the [lactate]/[pyruvate] ratio.