Effect of methylene blue on the disposition of ethanol

Citation
R. Vonlanthen et al., Effect of methylene blue on the disposition of ethanol, ALC ALCOHOL, 35(5), 2000, pp. 424-426
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
ALCOHOL AND ALCOHOLISM
ISSN journal
0735-0414 → ACNP
Volume
35
Issue
5
Year of publication
2000
Pages
424 - 426
Database
ISI
SICI code
0735-0414(200009/10)35:5<424:EOMBOT>2.0.ZU;2-H
Abstract
The effect of methylene blur on the disposition of ethanol was studied in r ats and humans. Methylene blue increased the metabolism of [C-14]ethanol to (CO2)-C-14 in isolated hepatocytes and in intact rats by 75% and 30%, resp ectively. In healthy volunteers, methylene blue did not affect the pharmaco kinetics of ethanol and did nor alleviate the ethanol-induced NAD redox; ch anges as reflected by the increase in the [lactate]/[pyruvate] ratio.