A facile approach to 5-trifluoromethylated 1,2,4-triazole derivatives

Citation
Qr. Wang et al., A facile approach to 5-trifluoromethylated 1,2,4-triazole derivatives, SYN COMMUN, 30(23), 2000, pp. 4255-4262
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
0039-7911 → ACNP
Volume
30
Issue
23
Year of publication
2000
Pages
4255 - 4262
Database
ISI
SICI code
0039-7911(2000)30:23<4255:AFAT51>2.0.ZU;2-5
Abstract
Ethyl (1,1,1-trifluoro-2-propylidene)carbazate is converted with tert-butyl hypochlorite to the 2-chloro-1,1,1-trifluoro-2-propyl azo compound 2, whic h reacts with antimony pentachloride to produce the trifluoromethylated 1-a za-2-azoniaallene salt 3 as a highly reactive intermediate. The cation 3 is employed as a CF3-containing synthon for the preparation of the 5-trifluor omethylated 1H-1,2,4-triazolium picrates 6a-e.