Nerve growth factor (NGF) and NGF mRNA change in rat uterus during pregnancy

Citation
Fg. Varol et al., Nerve growth factor (NGF) and NGF mRNA change in rat uterus during pregnancy, NEUROSCI L, 294(1), 2000, pp. 58-62
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
0304-3940 → ACNP
Volume
294
Issue
1
Year of publication
2000
Pages
58 - 62
Database
ISI
SICI code
0304-3940(20001110)294:1<58:NGF(AN>2.0.ZU;2-A
Abstract
During pregnancy, the uterus undergoes a profound sympathetic denervation. To explore whether this is associated with changes in neurotrophic factors, we assayed nerve growth factor (NGF) and NGF mRNA in the uterus of non-pre gnant and pregnant rats. In the uterine horn, the concentration of NGF and its mRNA decreased during middle and late pregnancy. However, when values w ere corrected for the increase of uterine weight and total RNA yield during pregnancy, NGF content and mRNA per horn increased during middle and late pregnancy. Similar, but less pronounced, changes were observed in the cervi x. By seven days postpartum, both parameters returned to near normal. (C) 2 000 Elsevier Science Ireland Ltd. All rights reserved.