High concentrations of serum inhibin in pre-eclampsia

Citation
T. Hamasaki et al., High concentrations of serum inhibin in pre-eclampsia, INT J GYN O, 71(1), 2000, pp. 7-11
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine
Journal title
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
ISSN journal
0020-7292 → ACNP
Volume
71
Issue
1
Year of publication
2000
Pages
7 - 11
Database
ISI
SICI code
0020-7292(200010)71:1<7:HCOSII>2.0.ZU;2-4
Abstract
Objective: To evaluate maternal serum immunoreactive inhibin (ir-inhibin) c oncentrations in women with preeclampsia, and assess the correlation betwee n serum ir-inhibin and HCG, Methods: The subjects comprised 28 pregnant wom en with suspected intrauterine growth retardation (IUGR) during the third t rimester. Serum concentrations of ir-inhibin and HCG were measured in 13 wo men with pre-eclampsia and 15 pregnant women as control subjects. Serum ir- inhibin was determined by a double antibody radioimmunoassay, and HCG by a solid-phase immunoradiometric assay. Results: There were no significant dif ferences in maternal characteristics between the pre-eclamptic group and co ntrol group. The pre-eclamptic group had significantly higher concentration s of serum ir-inhibin and HCG compared with the control group. The serum co ncentrations of ir-inhibin correlated positively with those of HCG, Conclus ion: The pre-eclamptic patients displayed high serum levels of ir-inhibin a nd HCG, and this might reflect hyperplasia of trophoblastic cells. (C) 2000 International Federation of Gynecology and Obstetrics. All rights reserved .