Tacrolimus (TAC) is a useful immunosuppressive agent in the prevention of r
ejection. However, the blood level between its therapeutic and toxic levels
is narrow such that its nephrotoxicity is a problem . Moreover, its bioava
ilability and pharmakokinetics are highly variable. We experienced a case o
f acute nephrotoxicity, in which the blood level rose about 10 times above
the expected level. We found a peculiar vacuolization in the transplant bio
psy specimen. This change showed a marked vacuolization of the tubular cell
s, suggestive of acute nephrotoxicity by TAC.