The likely transformation of papillary thyroid carcinoma into anaplastic carcinoma during postoperative radioactive iodine-131 therapy: Report of a case

Citation
K. Shingu et al., The likely transformation of papillary thyroid carcinoma into anaplastic carcinoma during postoperative radioactive iodine-131 therapy: Report of a case, SURG TODAY, 30(10), 2000, pp. 910-913
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
ISSN journal
0941-1291 → ACNP
Volume
30
Issue
10
Year of publication
2000
Pages
910 - 913
Database
ISI
SICI code
0941-1291(2000)30:10<910:TLTOPT>2.0.ZU;2-S
Abstract
We report herein a case of papillary carcinoma which appeared to transform into anaplastic carcinoma during postoperative radioactive iodine-131 (I-13 1) therapy. A 67-year-old man who was diagnosed as having papillary thyroid carcinoma with bilateral neck lymph node involvement and multiple lung met astases underwent total thyroidectomy prior to I-131 therapy. Immediately a fter a second course of I-131 therapy, the patient complained of right neck pain and swelling, and a biopsy of the swollen neck lymph node was taken. Histologic examination of this biopsy specimen revealed anaplastic carcinom a. With p53 immunohistochemical staining, both the primary tumor and the bi opsy specimen were positive. We speculate that first, some DNA damage in tu mor cells was induced by the initial I-131 therapy, but neither DNA repair nor cell apoptosis occurred because the p53 gene was already mutated; then further DNA damage was induced by the second I-131 therapy, leading to anap lastic transformation.