Serum levels of adhesion molecules in children and adolescents with immuneand non-immune thyroid diseases

Citation
A. Bossowski et al., Serum levels of adhesion molecules in children and adolescents with immuneand non-immune thyroid diseases, J PED END M, 13(8), 2000, pp. 1067-1072
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
ISSN journal
0334-018X → ACNP
Volume
13
Issue
8
Year of publication
2000
Pages
1067 - 1072
Database
ISI
SICI code
0334-018X(200009/10)13:8<1067:SLOAMI>2.0.ZU;2-0
Abstract
Serum levels of sICAM-1, sVCAM-1 and sP-selectin were determined in patient s with Graves' disease before and after 8 weeks and 24 months of methimazol e therapy, in levothyroxine suppressed patients with non-toxic nodular goit er, and in a group of healthy controls, to elucidate the relationship to ci rculating antithyroid antibodies and possible role of soluble adhesion mole cules as markers of inflammatory activity, sICAM-1, sVCAM-1, and sP-selecti n in patients with untreated hyperthyroidism were markedly elevated compare d with controls. After 8 weeks of methimazole treatment, the concentrations of these molecules dropped, but were still significantly higher than in he althy children, In patients with clinical and biochemical remission after 2 4 months of therapy, sICAM-1 values were on the verge of significance, but still higher than in the control group, whereas serum levels of sVCAM-1 and sP-selectin had normalized, Slightly higher ser um sICAM-1 values were obs erved in patients with non-toxic nodular goiter compared with healthy child ren.