Synthesis of high specific activity [ethyl-1, 2-H-3]-labeled chlorpyrifos oxon and diazoxon

Citation
Nj. Zhang et al., Synthesis of high specific activity [ethyl-1, 2-H-3]-labeled chlorpyrifos oxon and diazoxon, J LABEL C R, 43(13), 2000, pp. 1275-1282
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
0362-4803 → ACNP
Volume
43
Issue
13
Year of publication
2000
Pages
1275 - 1282
Database
ISI
SICI code
0362-4803(200011)43:13<1275:SOHSA[>2.0.ZU;2-5
Abstract
[Ethyl-1,2-H-3]Chlorpyrifos oxon and [ethyl-1,2-H-3]diazoxon were synthesiz ed at a specific activity of 79 and 58 Ci/mmol, respectively, by catalytic tritiation of the corresponding monovinyl analogs over Pd/C. The high speci fic activity results from isotope exchange of the terminal vinylic protons prior to saturation of the double bond. This radiosynthesis procedure is ap plicable to the toxicologically-important oxon metabolites of many commerci al O,O-diethyl phosphorothioate pesticides.