Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

Citation
K. Shimoda et al., Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function, IMMUNITY, 13(4), 2000, pp. 561-571
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
IMMUNITY
ISSN journal
1074-7613 → ACNP
Volume
13
Issue
4
Year of publication
2000
Pages
561 - 571
Database
ISI
SICI code
1074-7613(200010)13:4<561:TPARRI>2.0.ZU;2-W
Abstract
Janus kinases (Jaks) play an important role in signal transduction via cyto kine receptors. Tyk2 is a Janus kinase, and we developed tyk2-deficient mic e to study the requirement for tyk2 in vivo. Tyk2-deficient mice show no ov ert developmental abnormalities; however, they display a lack of responsive ness to a small amount of IFN alpha, although a high concentration of IFN a lpha can fully transduce its signal even in the absence of tyk2. Furthermor e, IL-12-induced T cell function is defective in these mice. In contrast, t hese mice respond normally to IL-6 and IL-10, both of which activate tyk2 i n vitro. These observations demonstrate that tyk2 plays only a restricted r ole in mediating IFN alpha -dependent signaling while being required in med iating IL-12-dependent biological responses.