Secretory phospholipase A(2) predicts impending acute chest syndrome in sickle cell disease

Citation
La. Styles et al., Secretory phospholipase A(2) predicts impending acute chest syndrome in sickle cell disease, BLOOD, 96(9), 2000, pp. 3276-3278
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BLOOD
ISSN journal
0006-4971 → ACNP
Volume
96
Issue
9
Year of publication
2000
Pages
3276 - 3278
Database
ISI
SICI code
0006-4971(20001101)96:9<3276:SPAPIA>2.0.ZU;2-A
Abstract
Acute chest syndrome (ACS) is the leading cause of death in sickle cell dis ease, Severe ACS often develops in the course of a vasoocclusive crisis (VO C), but currently there are no predictors for its development. Secretory ph ospholipase A(2) (sPLA(2)), a potent inflammatory mediator, is elevated in ACS, and previous work suggests that sPLA(2) predicts impending ACS. We pro spectively evaluated sPLA(2) concentration during 21 admissions for VOC; 6 of these patients went on to develop ACS, Elevation of sPLA(2) was detected all 6 patients 24 to 48 hours before ACS was clinically diagnosed. Adding the requirement for fever raised the specificity of sPLA(2) to 87% while re taining 100% sensitivity. These data indicate that sPLA(2) can be useful in alerting the clinician to patients with impending ACS, In addition, sPLA(2 ) may be useful for instituting early therapies to prevent or reduce the cl inical morbidity of ACS, (C) 2000 by The American Society Hematology.