Regional specificity of localized cortical lesions in West syndrome

Citation
Si. Hamano et al., Regional specificity of localized cortical lesions in West syndrome, PED NEUROL, 23(3), 2000, pp. 219-224
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
PEDIATRIC NEUROLOGY
ISSN journal
0887-8994 → ACNP
Volume
23
Issue
3
Year of publication
2000
Pages
219 - 224
Database
ISI
SICI code
0887-8994(200009)23:3<219:RSOLCL>2.0.ZU;2-R
Abstract
West syndrome, although classified as a generalized epilepsy, is associated with localized cerebral lesions in some cases. However, similar localized cortical abnormalities usually can result in partial epilepsy, instead of W est syndrome. We performed this study to determine the additional factors t hat result in West syndrome instead of partial epilepsy in patients with lo calized cerebral lesions. We reviewed the pathologic features, topographic localization, and side of unilaterally defined cerebral lesions in relation to the seizure types in 39 epileptic patients, including five patients who presented with West syndrome. The lesions of all five patients with West s yndrome involved the temporal or occipital lobes (or both). Among the nine with an occipital lesion, four had West syndrome. In the 19 with a temporal lesion, three had West syndrome. However, in the 16 patients with a fronta l lesion, none exhibited epileptic spasms. In four of the five with West sy ndrome the lesions were on the right side; 23 had lesions on the right, 16 had them on the left. Temporo-occipital lesions and lesions on the right we re related to the genesis of West syndrome, which would be in close correla tion with normal brain maturation. (C) 2000 by Elsevier Science Inc. All ri ghts reserved.