Expression of perforin and Fas ligand mRNA in the liver of viral hepatitis

Citation
M. Tagashira et al., Expression of perforin and Fas ligand mRNA in the liver of viral hepatitis, J CLIN IMM, 20(5), 2000, pp. 347-353
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
JOURNAL OF CLINICAL IMMUNOLOGY
ISSN journal
0271-9142 → ACNP
Volume
20
Issue
5
Year of publication
2000
Pages
347 - 353
Database
ISI
SICI code
0271-9142(200009)20:5<347:EOPAFL>2.0.ZU;2-M
Abstract
Cytotoxic T lymphocytes (CTLs) play an important role in the pathogenesis o f viral hepatitis. We studied the expression of mRNAs of perforin and Fas l igand (Fas-L) in biopsy specimens from chronic hepatitis B (CHB) (15 cases) and hepatitis C (CHC) patients (13 cases). Both perforin and Fas-L mRNAs w ere detected in all cases of both CHB and CHC. No messages were detected in the control livers from two cases of fatty liver, a case of Gilbert's synd rome, and a case of Dubin-Johnson syndrome. Semiquantitative analysis revea led a positive correlation between the intensity of perforin and Fas-L mRNA s in both CHB and CHC. In CHB, the intensity of both perforin and Fas-L mRN As showed a positive correlation with the histological activity and serum a lanine aminotransferase level, while the correlation was not apparent in CH C. These results suggest that both perforin and Fas/Fas-L systems are invol ved in the pathogenesis of liver cell injury of CHB and CHC.