Detection rates of TT virus DNA in serum of umbilical cord blood, breast milk and saliva

Citation
K. Goto et al., Detection rates of TT virus DNA in serum of umbilical cord blood, breast milk and saliva, TOH J EX ME, 191(4), 2000, pp. 203-207
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research General Topics
Journal title
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
ISSN journal
0040-8727 → ACNP
Volume
191
Issue
4
Year of publication
2000
Pages
203 - 207
Database
ISI
SICI code
0040-8727(200008)191:4<203:DROTVD>2.0.ZU;2-9
Abstract
To date, the routes of mother-to-infant transmission of TT virus (TTV) have not been fully elucidated. The present study examines the detection rates of TTV DNA. in the serum of pregnant Japanese women and in cord blood at th e time of delivery, as well as in the saliva and breast milk of mothers one -month postpartum. Primers derived from the well-known translated region N2 2 (N22 system), as well as the untranslated region (UTR system) were used. The prevalence of TTV DNA in the serum of pregnant women was found to be 11 .9% (19/160) using the N22 system and 72.4% (55/76) using the UTR system. N o TTV DNA was detected in the cord blood samples (0/160) when the N22 syste m was used for detection but TTV DNA was detected in 11.8% (7/76) of sample s studied with the UTR system. Using the N22 system, TTV DNA was not detect ed in breast milk, but was detected in saliva. However using the UTR system , TTV DNA was detected in both specimens. These results imply that some bab ies are vertically infected with TTV via cord blood at the time of delivery or via breast milk or saliva. However, further research is necessary to co nfirm this hypothesis.