Renal protective effect of troglitazone in Wistar fatty rats

Citation
K. Fujiwara et al., Renal protective effect of troglitazone in Wistar fatty rats, METABOLISM, 49(10), 2000, pp. 1361-1364
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN journal
0026-0495 → ACNP
Volume
49
Issue
10
Year of publication
2000
Pages
1361 - 1364
Database
ISI
SICI code
0026-0495(200010)49:10<1361:RPEOTI>2.0.ZU;2-J
Abstract
Although it is known that renal injury develops in obesity and diabetes mel litus, there have been no investigations examining the impact of insulin re sistance per se on the development of renal injury. The present study was u ndertaken to examine whether insulin resistance and obesity influence urina ry protein excretion (UPE) in female heminephrectomized Wistar fatty rats ( WFRs). After 24 weeks of heminephrectomy in WFRs, the body weight ([BW], 46 5 +/- 18 g; n = 6), blood pressure (155 +/- 5 mm Hg), serum insulin to gluc ose ratio (1.31 +/- 0.39 mu U/mg), and daily UPE (24 +/- 7 mg/d) were great er Versus Wistar lean rats ([WLRs] 258 +/- 8 g, 134 +/- 1 mm Hg, 0.19 +/- 0 .06 mu U/mg, and 5 +/- 1 mg/d, respectively; n = 6), whereas blood glucose levels did not increase significantly. In WFRs, long-term (ie, 24 weeks) tr eatment with trogritazone, an insulin-sensitizing agent, improved the serum insulin to glucose ratio (0.17 +/- 0.09 mu U/mg), reduced blood pressure ( to 140 +/- 4 mm Hg), and decreased UPE (to 7 +/- mg/d), although it had no effect on BW. Of note, with troglitazone treatment, the reduction in protei nuria preceded the correction of hypertension (ie, at week 12). In conclusi on, our study suggests that insulin resistance per se causes proteinuria th at does not appear to depend on blood pressure. Furthermore, long-term ther apy with troglitazone may be a useful tool for the treatment of renal injur y in the insulin-resistant condition. Copyright (C) 2000 by W.B. Saunders C ompany.