Hospital disinfectants and spore formation by Clostridium difficile

Citation
Mh. Wilcox et Wn. Fawley, Hospital disinfectants and spore formation by Clostridium difficile, LANCET, 356(9238), 2000, pp. 1324-1324
Citations number
5
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
0140-6736 → ACNP
Volume
356
Issue
9238
Year of publication
2000
Pages
1324 - 1324
Database
ISI
SICI code
0140-6736(20001014)356:9238<1324:HDASFB>2.0.ZU;2-4
Abstract
Evidence Is lacking on how best to decontaminate the hospital environment o f Clostridium difficile. We compared sporulation levels in the UK epidemic C difficile strain (P24), another clinical isolate (B31), and an environmen tal strain (E4) cultured in faecal emulsion containing subinhibitory concen trations of one of five hospital cleaning agents. The epidemic strain produ ced significantly more spares than the nan-prevalent strains, and sporulati on was further enhanced when this strain was cultured in faeces exposed to non-chlorine-based cleaning agents. The choice of cleaning agent can have a substantial effect on the persistence of C difficile spores in the hospita l environment.