This study investigated the aetiology of nausea and vomiting in pregnancy (
NVP) in primary care using a new methodology. Eighteen women in early pregn
ancy had 2 blood samples taken in one 24-hour time period, one when they we
re symptomatic, and another when they were symptom-free. Maternal serum lev
els of the candidate agents PGE2, IL-1 beta, and TNF alpha were measured. T
he study shows a positive relationship between NVP and maternal serum PGE2
levels in early pregnancy. Copyright (C) 2000 S. Karger AG, Basel.