Changes in plasma adenosine concentrations during normal pregnancy

Citation
Y. Yoneyama et al., Changes in plasma adenosine concentrations during normal pregnancy, GYNECOL OBS, 50(3), 2000, pp. 145-148
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
50
Issue
3
Year of publication
2000
Pages
145 - 148
Database
ISI
SICI code
0378-7346(2000)50:3<145:CIPACD>2.0.ZU;2-W
Abstract
The aim of this study was to measure changes in plasma adenosine concentrat ion [ADO] during a normal pregnancy and to evaluate the possible role of pl atelets and red blood cells (RBC) as causes of changes in plasma [ADO], We measured the plasma [ADO] in normal pregnant women (n = 11) during the firs t, second and third trimesters, The mean plasma [ADO] in the third trimeste r was 0.41 +/- 0.08 mu M(means +/- SEM), significantly higher than in the f irst and second trimesters (p < 0.05). In pregnant women, platelet and RBC counts, hematocrit and hemoglobin concentration decreased slightly througho ut the pregnancy. The elevation in the plasma [ADO] correlated inversely wi th the platelet count (r = -0.43, p < 0.05), These results suggest that an increase in the plas ma [ADO] in the third trimester may be attributed to t he enhanced adenosine release from activated platelets. Copyright (C) 2000 S. Karger AG, Basel.