The association between vascular endothelial growth factor, microvessel density and clinicopathological features in invasive cervical cancer

Citation
W. Tjalma et al., The association between vascular endothelial growth factor, microvessel density and clinicopathological features in invasive cervical cancer, EUR J OB GY, 92(2), 2000, pp. 251-257
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
ISSN journal
0301-2115 → ACNP
Volume
92
Issue
2
Year of publication
2000
Pages
251 - 257
Database
ISI
SICI code
0301-2115(200010)92:2<251:TABVEG>2.0.ZU;2-K
Abstract
Objective: The aim of this study was to analyse the vascular endothelial gr owth factor (VEGF) expression in a series of cervical carcinomas and to com pare the results with the microvessel density (MVD) and clinicapathological features. Study design: The immunoreactivity for VEGF was studied in 130 i nvasive cervical carcinomas and in 22 patients with a carcinoma in situ of the cervix. The results were compared with the MVD. Results: Staining for V EGF of less then 50% per slide occurred in 80% of the invasive carcinomas a nd in 82% of the in situ carcinomas. The median MVD was 261 vv/mm(2) (range : 11-1000) in the invasive group and 146 vv/mm(2) (range: 25-536) in the in situ group, Unlike the microvessel density there was no association betwee n VEGF expression and survival. The MVD was higher in VEGF poorer (<50%) tu mours (P = 0,055). Beside tumour histology (P = 0.012) there were no other significant relationships between the remaining histopathological findings and VEGF expression. Conclusion: Tissue VEGF expression has:no prognostic v alue in contrast with the MVD in patients with invasive cervical cancer. (C ) 2000 Elsevier Science Ireland Ltd. All rights reserved.