Vancomycin-resistant enterococci

Citation
Y. Cetinkaya et al., Vancomycin-resistant enterococci, CLIN MICROB, 13(4), 2000, pp. 686
Citations number
242
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
CLINICAL MICROBIOLOGY REVIEWS
ISSN journal
0893-8512 → ACNP
Volume
13
Issue
4
Year of publication
2000
Database
ISI
SICI code
0893-8512(200010)13:4<686:VE>2.0.ZU;2-F
Abstract
After they were first identified in the mid-1980s, vancomycin-resistant ent erococci (VRE) spread rapidly and became a major problem in many institutio ns both in Europe and the United States. Since VRE have intrinsic resistanc e to most of the commonly used antibiotics and the ability to acquire resis tance to most of the current available antibiotics, either by mutation or b y receipt of foreign genetic material they have a selective advantage over other microorganisms in the intestinal flora and pose a major therapeutic c hallenge. The possibility of transfer of vancomycin resistance genes to oth er gram-positive organisms raises significant concerns about the emergence of vancomycin-resistant Staphylococcus aureus. We review VRE, including the ir history, mechanisms of resistance, epidemiology, control measures, and t reatment.