Fungal and parasitic infections of the eye

Citation
Sa. Klotz et al., Fungal and parasitic infections of the eye, CLIN MICROB, 13(4), 2000, pp. 662
Citations number
304
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
CLINICAL MICROBIOLOGY REVIEWS
ISSN journal
0893-8512 → ACNP
Volume
13
Issue
4
Year of publication
2000
Database
ISI
SICI code
0893-8512(200010)13:4<662:FAPIOT>2.0.ZU;2-B
Abstract
The unique structure of the human eye as well as exposure of the eye direct ly to the environment renders it vulnerable to a number of uncommon infecti ons diseases caused by fungi and parasites. Host defenses directed against these microorganisms, once anatomical barriers are breached, are often insu fficient to prevent loss of vision. Therefore, the timely identification an d treatment of the involved microorganisms are paramount. The anatomy of th e eye and its surrounding structures is presented with an emphasis upon the association of the anatomy with specific infection of fungi and parasites. For example, filamentous fungal infections of the eye are usually due to p enetrating trauma by objects contaminated by vegetable matter of the cornea or globe or, by extension, of infection from adjacent paranasal sinuses. F ungal endophthalmitis and chorioretinitis, on the other hand are usually th e result of antecedent fungemia seeding the ocular tissue. Candida spp. nle the most common cause of endogenous endophthalmitis, although initial infe ction with the dimorphic fungi may lead to infection and scarring of the ch orioretina. Contact lens Mmr is associated with keratitis caused by yeasts, filamentous fungi, and Acanthamoebae spp. Most parasitic infections of the eye, however, arise following bloodborne carriage of the microorganism to the eye or adjacent structures.