Interference of antibacterial agents with phagocyte functions: Immunomodulation or "immuno-fairy tales"?

Authors
Citation
Mt. Labro, Interference of antibacterial agents with phagocyte functions: Immunomodulation or "immuno-fairy tales"?, CLIN MICROB, 13(4), 2000, pp. 615
Citations number
417
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
CLINICAL MICROBIOLOGY REVIEWS
ISSN journal
0893-8512 → ACNP
Volume
13
Issue
4
Year of publication
2000
Database
ISI
SICI code
0893-8512(200010)13:4<615:IOAAWP>2.0.ZU;2-L
Abstract
Professional phagocytes (polymorphonuclear neutrophils and monocytes/macrop hages) are a main component of the immune system. These cells are involved in both host defenses and various pathological settings characterized by ex cessive inflammation. Accordingly, they are key targets for immunomodulator y drugs, among which antibacterial agents are promising candidates. The bas ic and historical concepts of immunomodulation will first be briefly review ed. Phagocyte complexity will then be unravelled (at least in terms of what we know about the origin, subsets, ambivalent roles, functional capacities , and transductional pathways of this cell and how to explore them). The co re subject of this review will be the manu possible interactions between an tibacterial agents and phagocytes, classified according to demonstrated or potential clinical relevance (e.g., neutropenia, intracellular accumulation , and modulation of bacterial virulence). A detailed review of direct in vi tro effects will be provided for the various antibacterial drug families, f ollowed by a discussion of the clinical relevance of these effects in two p articular settings: immune deficiency and inflammatory diseases. The prophy lactic and therapeutic rise of immunomodulatory antibiotics will be conside red before conclusions me drawn about the emerging (optimistic) vision of f uture therapeutic prospects to deal with largely unknown new diseases and n ew pathogens by using new agents, new techniques, and a better understandin g of the phagocyte in particular and the immune system in general.