Increased plasma levels of tissue factor pathway inhibitor-activated factor X complex in patients with disseminated intravascular coagulation

Citation
Y. Okugawa et al., Increased plasma levels of tissue factor pathway inhibitor-activated factor X complex in patients with disseminated intravascular coagulation, AM J HEMAT, 65(3), 2000, pp. 210-214
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF HEMATOLOGY
ISSN journal
0361-8609 → ACNP
Volume
65
Issue
3
Year of publication
2000
Pages
210 - 214
Database
ISI
SICI code
0361-8609(200011)65:3<210:IPLOTF>2.0.ZU;2-7
Abstract
Plasma levels of tissue factor pathway inhibitor (TFPI)-activated factor Xa (FXa) complex were measured in patients with disseminated intravascular co agulation (DIC), pre-DIG, and DIG. Plasma levels of plasmin-plasmin inhibit or complex (PPIC), D-dimer, and soluble fibrin monomer (SFM) were significa ntly higher in patients with DIG than in those with pre-DIG or non-DIG; the levels of these hemostatic markers were significantly higher in patients w ith pre-DIG than in those with non-DIG. Plasma levels of thrombin-antithrom bin complex (TAT) were significantly higher in patients with DIG or pre-DIG than in those with non-DIG. Plasma levels of tissue factor (TF), total TFP I, free TFPI, and TFPI-Xa complex were significantly higher in patients wit h DIG than in those with non-DIC. Plasma levels of TFPI-Xa complex were sig nificantly increased in patients with pre-DIG as compared to those with non -DIG; however, plasma free TFPI levels were significantly decreased in pati ents with pre-DIG as compared to those with non-DIG. These findings suggest that free TFPI might be consumed in the pre-DIG state, thereby confirming the activation of the extrinsic pathway. Plasma levels of TFPI-Xa complex w ere significantly correlated with TF, free TFPI, and total TFPI. Increased plasma TFPI-Xa complex levels might be useful for the diagnosis of DIG or p re-DIG, particularly that occurring by activation of the extrinsic pathway of blood coagulation. (C) 2000 Wiley-Liss, Inc.