Role of nociceptin systems in learning and memory

Citation
Y. Noda et al., Role of nociceptin systems in learning and memory, PEPTIDES, 21(7), 2000, pp. 1063-1069
Citations number
51
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
0196-9781 → ACNP
Volume
21
Issue
7
Year of publication
2000
Pages
1063 - 1069
Database
ISI
SICI code
0196-9781(200007)21:7<1063:RONSIL>2.0.ZU;2-8
Abstract
This article summarizes our recent finding that the nociceptin system is in volved in the regulation of learning and memory. The nociceptin-knockout mi ce show greater learning ability in the water maze task, an enhanced latent learning in the water finding task, better memory in the passive avoidance task, and further, larger long-term potentiation in the hippocampal CA1 re gion than wild-type mice. Nociceptin itself induces an impairment of passiv e avoidance task in wild-type mice, which is reversed by naloxone benzoylhy drazone (NalBzoH). Thus, the nociceptin system seems to play negative roles in learning and memory, and NalBzoH may act as a potent antagonist for the nociceptin receptor. (C) 2000 Elsevier Science Inc. All rights reserved.