Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

Citation
Yq. Wei et al., Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine, NAT MED, 6(10), 2000, pp. 1160-1166
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
NATURE MEDICINE
ISSN journal
1078-8956 → ACNP
Volume
6
Issue
10
Year of publication
2000
Pages
1160 - 1166
Database
ISI
SICI code
1078-8956(200010)6:10<1160:IOTWXE>2.0.ZU;2-H
Abstract
The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that imm unotherapy of tumors using fixed xenogeneic whole endothelial cells as a va ccine was effective in affording protection from tumor growth, inducing reg ression of established tumors and prolonging survival of tumor-bearing mice . Furthermore, autoreactive immunity targeting to microvessels in solid tum ors was induced and was probably responsible for the anti-tumor activity. T hese observations may provide a new vaccine strategy for cancer therapy thr ough the induction of an autoimmune response against the tumor endothelium in a cross-reaction.