Antimutagenic activity of 5 alpha-cholest-7-en-3 beta-ol, a new component from the starfish Asterina pectinifera

Citation
Yh. Han et al., Antimutagenic activity of 5 alpha-cholest-7-en-3 beta-ol, a new component from the starfish Asterina pectinifera, BIOL PHAR B, 23(10), 2000, pp. 1247-1249
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
23
Issue
10
Year of publication
2000
Pages
1247 - 1249
Database
ISI
SICI code
0918-6158(200010)23:10<1247:AAO5AB>2.0.ZU;2-W
Abstract
From the butanol fraction of the starfish Asterina pectinifera MULER et TRO SCHEL (Asteriidae), we have isolated a new component, 5 alpha-cholest-7-en- 3 beta-ol. Its antigenotoxic and antimutagenic activities were examined by the SOS chromotest,vith Escherichia coli PQ37 and by Ames test with Salmone lla typhimurium TA1538, respectively 5 alpha-Cholest-7-en-3 beta-ol showed potent antigenotoxic activity against the mutagens, both MNNG and NQO, For 100% of antigenotoxicity the concentration of the compound applied against MNNG and NQO were 10 mu g and 5 mu g per reaction tube, respectively, Its a ntimutagenic activity with S, typhimurium TA1538 against the mutagen MNNG w as very effective. When its concentrations were varied from 1 up to 10 mu g dose per plate, the inhibition ratio of revertant CFU of TA1538 per plate was increased accordingly from 25.2 to 99.2%, These results suggest that 5 alpha-cholest-7-en-3 beta-ol possesses antigenotoxic and antimutagenic acti vity and might be useful as a chemopreventive agent.