Convenient syntheses of biologically relevant vinyl and divinyl phosphatesby selective dealkylation of the corresponding phosphites

Citation
Nj. Zhang et Je. Casida, Convenient syntheses of biologically relevant vinyl and divinyl phosphatesby selective dealkylation of the corresponding phosphites, SYNTHESIS-S, (10), 2000, pp. 1454-1458
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
0039-7881 → ACNP
Issue
10
Year of publication
2000
Pages
1454 - 1458
Database
ISI
SICI code
0039-7881(200009):10<1454:CSOBRV>2.0.ZU;2-K
Abstract
Reactions of diethyl vinyl phosphite and divinyl methyl phosphite with iodi ne produce exclusively dealkylated intermediates, the highly reactive vinyl and divinyl phosphoroiodidates, which can be used as efficient phosphoryla tion reagents to prepare a variety of vinyl and divinyl organophosphorus co mpounds. Examples are given for the ethyl vinyl and divinyl analogs of the potent diethyl phosphate anticholinesterase agents diazoxon, chlorpyrifos o xon and paraoxon.