Reactions of diethyl vinyl phosphite and divinyl methyl phosphite with iodi
ne produce exclusively dealkylated intermediates, the highly reactive vinyl
and divinyl phosphoroiodidates, which can be used as efficient phosphoryla
tion reagents to prepare a variety of vinyl and divinyl organophosphorus co
mpounds. Examples are given for the ethyl vinyl and divinyl analogs of the
potent diethyl phosphate anticholinesterase agents diazoxon, chlorpyrifos o
xon and paraoxon.