Synthesis, characterization, and antitumour activity of isonicotinamido-4-bis(2-chloroethyl)aminobenzaldimine complexes of some transition metals

Citation
Cz. Li et al., Synthesis, characterization, and antitumour activity of isonicotinamido-4-bis(2-chloroethyl)aminobenzaldimine complexes of some transition metals, CHEM PAP-CH, 54(4), 2000, pp. 239-244
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
CHEMICAL PAPERS-CHEMICKE ZVESTI
ISSN journal
0366-6352 → ACNP
Volume
54
Issue
4
Year of publication
2000
Pages
239 - 244
Database
ISI
SICI code
0366-6352(2000)54:4<239:SCAAAO>2.0.ZU;2-M
Abstract
Isonicotinamido-4-bis(2-chloroethyl)aminobenzaldimine (IBAB) was synthesize d through multistep reactions and characterized by spectral methods. The co mplexes M(IBAB)(2)(NO3)(2) (M = copper(II), nickel(II), cobalt(II), iron(II I), zinc(II), and cadmium(II)) were isolated and characterized by elemental analysis, IR, UV VIS, and EPR spectra. The results show that IBAB binding to the metals is bidentate. In copper complex, IBAB is coordinated to the m etal through carbonyl oxygen and azomethine nitrogen atoms. In the other co mplexes, which can form polymeric structure, IBAB is coordinated to the met al ions via amide nitrogen and pyridine nitrogen atom. The molar conductivi ty and spectral data suggest an octahedral geometry for the nickel(II), cob alt(II), and iron(III) complexes, a planar geometry for the copper(II) comp lex and a tetrahedral stereochemistry for the zinc(II) and cadmium(II) comp lexes. The data of antitumour activities indicate that the complexes have a definite cytotoxicity effect.