Glutamate receptors participate in the nicotine-induced changes of met-enkephalin in striatum

Citation
R. Isola et al., Glutamate receptors participate in the nicotine-induced changes of met-enkephalin in striatum, BRAIN RES, 878(1-2), 2000, pp. 72-78
Citations number
53
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
0006-8993 → ACNP
Volume
878
Issue
1-2
Year of publication
2000
Pages
72 - 78
Database
ISI
SICI code
0006-8993(20000929)878:1-2<72:GRPITN>2.0.ZU;2-6
Abstract
A single dose of nicotine given to mice induces first a rapid decrease (pre sumed release/enhanced degradation) and then a rise (presumed synthesis/enh anced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral stria tum observed at 30 and 60 min post-treatment, respectively. These studies i nvestigated whether the nicotine effect on NIet-Enk was mediated indirectly , in part, via other neurotransmitters known to be released by nicotine. Ba sed on the ability of selective antagonists of dopamine (Sch 23390, D1; Sul piride, D2), glutamate (CPP, competitive NMDA; dizocilpine, non-competitive NMDA; NBQX, AMPA) and GABA (bicuculline, GABA(A); Sch 50911. GABA(B)) rece ptors, to inhibit or enhance the response to nicotine, we conclude that nic otine alters striatal Met-Enk, in part, via glutamate NMDA and AMPA recepto rs. These findings further support the notion that glutamate might play a r ole in the pharmacology of nicotine. (C) 2000 Elsevier Science B.V. All rig hts reserved.