The odontoclasts of Ambystoma mexicanum

Citation
J. Wistuba et al., The odontoclasts of Ambystoma mexicanum, ANN ANATOMY, 182(5), 2000, pp. 415-422
Citations number
49
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
ISSN journal
0940-9602 → ACNP
Volume
182
Issue
5
Year of publication
2000
Pages
415 - 422
Database
ISI
SICI code
0940-9602(200009)182:5<415:TOOAM>2.0.ZU;2-F
Abstract
The resorption of teeth in Ambystoma mexicanum during postembryonal ontogen esis and induced metamorphosis occurs by means of light-microscopic detecta ble giant-cells. These have morphological and functional characters similar to those of odontoclasts of other vertebrates. The multinucleated odontocl asts resorb not only the pedicel (base), but the stalk of the tooth, too. W hen active, the cells form a ruffled border and a sealing zone. In this way they are able to demineralize the hard tissues of teeth (dentin and minera l of the pedicel) and to dissolve the extracellular matrix. Resorption of e namel has not been observed. Marks of resorption resemble the Howship's lac unae of other tetrapods. TRAP as a typical enzyme of odontoclasts could not be detected histochemically. Dependence of PTH, which is supposed to be ne cessary for the formation and activation of odontoclasts as well as of thyr oxine can be excluded, although the resorbing cells are functionally and cy tologically identical with those of other vertebrates. This demands some ot her mechanism for the formation and regulation of the odontoclasts in A. me xicanum.