A study of the apparent diffusion coefficient of grey and white matter in human ischaemic stroke

Citation
Me. Bastin et al., A study of the apparent diffusion coefficient of grey and white matter in human ischaemic stroke, NEUROREPORT, 11(13), 2000, pp. 2867-2874
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
11
Issue
13
Year of publication
2000
Pages
2867 - 2874
Database
ISI
SICI code
0959-4965(20000911)11:13<2867:ASOTAD>2.0.ZU;2-R
Abstract
We examined whether there was any difference in the value, and temporal evo lution, of the apparent diffusion tensor trace ((ADC) over bar) in acute an d subacute grey and white matter lesions. Thirty-seven patients underwent d iffusion imaging once (up to 3 days), 15 patients were scanned Mice (up to 7 days), and seven patients were scanned three times (up to 14 days) after stroke. Values of the ratio of ischaemic to contralateral (ADC) over bar (< (ADCr)over bar>) were reduced on average by 30% (p < 0.001) in the whole hy perintense region up to 7 days post-ictus. No difference was seen between < (ADCr)over bar> values of grey and white matter in individual subjects with in the patient groups scanned up to 7 days. However, in the subgroup of pat ients scanned beyond 7 days, <(ADCr)over bar> for grey matter rose signific antly (p = 0.02) from <(ADCr)over bar> similar to 0.7 (< 7 days) to 0.95 (g reater than or equal to 10 days). This increase did not occur in white matt er whose <(ADCr)over bar> remained fairly constant (<(ADCr)over bar> simila r to 0.7) over the time course of the study. NeuroReport 11:2867-2874 (C) 2 000 Lippincott Williams & Wilkins.